Hydrogen chloride-ethyl acetate → HCID 118023881, compound

HRID 2171810Notes

Reaction equation

HRID 2171810 reaction equation
[CH:1]1([C:7]2[S:25][C:10]3[N:11]=[C:12]([CH3:24])[N:13]=[C:14]([CH2:15][N:16]4[CH2:21][CH2:20][O:19][C:18]([CH3:23])([CH3:22])[CH2:17]4)[C:9]=3[CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:26].CCOC(C)=O>CCOC(C)=O>[ClH:26].[CH:1]1([C:7]2[S:25][C:10]3[N:11]=[C:12]([CH3:24])[N:13]=[C:14]([CH2:15][N:16]4[CH2:21][CH2:20][O:19][C:18]([CH3:22])([CH3:23])[CH2:17]4)[C:9]=3[CH:8]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 118023509HCID 118023509, compound

Product 1

HCID 118023881HCID 118023881, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a mixture of 6-cyclohexyl-4-[(2,2-dimethylmorpholin-4-yl)methyl]-2-methylthieno[2,3-d]pyrimidine (130 mg) and EtOAc (2 mL) was added 4 M HCl/EtOAc (100 μL), followed by stirring at room temperature. The precipitated solid was collected by filtration to obtain 6-cyclohexyl-4-[(2,2-dimethylmorpholin-4-yl)methyl]-2-methylthieno[2,3-d]pyrimidine hydrochloride (90 mg).

Workup

  1. filtrationThe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-1d3f4ff044174e59b7181d603b293be5
Source dataset
uspto-grants-2015_06
Patent number
US09051339B2

Reaction notes

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