Ammonium Hydroxide → HCID 67303888, compound

HRID 2172209Notes

Reaction equation

HRID 2172209 reaction equation
[NH4+:1].[OH-].C[O:4][C:5](=O)[CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][C:15]([F:18])([F:17])[F:16])=[CH:10][CH:9]=1>CO>[F:16][C:15]([F:18])([F:17])[O:14][C:11]1[CH:12]=[CH:13][C:8]([O:7][CH2:6][C:5]([NH2:1])=[O:4])=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 70873584HCID 70873584, compound

Product 1

HCID 67303888HCID 67303888, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A 25% ammonia aqueous solution (20 ml) was added to (4-trifluoromethoxyphenoxy)acetic acid methyl ester in methanol (40 ml) and the mixture was stirred at room temperature overnight. After distilling the solvent off, the residue was washed with water and dried to afford the title compound as a white solid (12.1 g, yield 91%).

Workup

  1. distillationAfter distilling the solvent off, the residue
  2. washwas washed with water
  3. customdried

Sources & evidence

ORD record
ord-ad13d7e57a3e4972af851766e0ecca7f
Source dataset
uspto-grants-2015_06
Patent number
US09051333B2

Reaction notes

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