Formaldehyde → Ethyl 2-(4-bromophenyl)acrylate

HRID 2172347Notes

Reaction equation

HRID 2172347 reaction equation
[CH2:1]([O:3][C:4](=[O:13])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][CH:7]=1)[CH3:2].C=O.[C:16](=O)([O-])[O-].[K+].[K+]>[I-].C([N+](CCCC)(CCCC)CCCC)CCC.C1(C)C=CC=CC=1>[CH2:1]([O:3][C:4](=[O:13])[C:5]([C:6]1[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][CH:7]=1)=[CH2:16])[CH3:2]

Participants

6

Reactant 3

HCID 712FormaldehydeHCID 11430Potassium CarbonateHCID 7020609Ethyl 2-(4-bromophenyl)acetate

Product 1

HCID 11470828Ethyl 2-(4-bromophenyl)acrylate

Reagents, catalysts & solvents 2

HCID 67553Tetrabutylammonium IodideCatalystHCID 1140TolueneSolvent

Procedure

is prepared by treating a toluene solution of (4-bromo-phenyl)-acetic acid ethyl ester with paraformaldehyde, potassium carbonate, tetrabutylammonium iodide according to the following literature: H. Stalder, M. Boes Chimia 2000, 54, 669-671.

Workup

  1. customis prepared

Sources & evidence

ORD record
ord-0ce283c2bbad4867ad6caa8597cb1b33
Source dataset
uspto-grants-2015_06
Patent number
US09051448B2

Reaction notes

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