Thionyl Chloride → HCID 12561346, compound

HRID 2172348Notes

Reaction equation

HRID 2172348 reaction equation
[C:1]1([C:7](=[CH2:11])[C:8](O)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:14])=O.C(C1C=CC=C(O)C=1O)(C)(C)C>CN(C=O)C>[C:1]1([C:7](=[CH2:11])[C:8]([Cl:14])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 24386Thionyl ChlorideHCID 68114Atropic acidHCID 77643tert-Butylcatechol

Product 1

HCID 12561346HCID 12561346, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

and is prepared by treating a DMF solution of 2-phenyl-acrylic acid with thionyl chloride in the presence of tert-butylcatechol to afford 2-phenyl-acryloyl chloride. The latter is subsequently treated with a 30% aqueous solution of ammonia according to the following literature: K. Nishiyama, Y. Inouye Agric. Biol. Chem. 1982, 46, 1027-1034.

Workup

  1. customand is prepared

Sources & evidence

ORD record
ord-3c925bd3b39b4b7a9116d6786224bbbe
Source dataset
uspto-grants-2015_06
Patent number
US09051448B2

Reaction notes

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