Trifluoroacetic acid → HCID 86672757, compound

HRID 2172967Notes

Reaction equation

HRID 2172967 reaction equation
C(OC(=O)[NH:7][C:8]1([C:11]2[CH:16]=[CH:15][N:14]=[C:13]([Br:17])[CH:12]=2)[CH2:10][CH2:9]1)(C)(C)C.[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22]>ClCCl>[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22].[Br:17][C:13]1[CH:12]=[C:11]([C:8]2([NH2:7])[CH2:9][CH2:10]2)[CH:16]=[CH:15][N:14]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 72213060HCID 72213060, compound

Product 1

HCID 86672757HCID 86672757, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of [1-(2-bromo-pyridin-4-yl)-cyclopropyl]-carbamic acid tert-butyl ester (0.160 g, 0.511 mmol) in dichloromethane (3 mL) is added trifluoroacetic acid (1.0 mL, 13 mmol) at room temperature. After 18 hours, the reaction mixture is concentrated in vacuo to yield crude title compound (ES+ m/z 213.49, 215.40) as an oil, which is used without purification.

Workup

  1. concentrationthe reaction mixture is concentrated in vacuo

Sources & evidence

ORD record
ord-5d56619915164a42bad3c17135173e67
Source dataset
uspto-grants-2015_06
Patent number
US09056858B2

Reaction notes

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