反应详情

温度

23 °C

Triethylamine (735 mL, 5.30 mol) is added dropwise at 0° C. under N2 over 40 minutes to a solution of di-tert-butyl(2S,4S)-2-[(tert-butoxycarbonyl)amino]-4-hydroxybicyclo[3.1.0]hexane-2,6-dicarboxylate (995.4 g, 2.41 mol) in dry tetrahydrofuran (8.4 L) Methanesulfonyl chloride (373 mL, 4.82 mol) is added at 0° C. over 50 minutes. The reaction is warmed to 23° C. After 3 hours, the reaction if filtered to remove triethylamine hydrochloride salt. Wash the filter cake with dry tetrahydrofuran (2×2 L). The filtrate (13 L) is split into two equal parts. To one half of filtrate, add 1M potassium tert-butoxide in tetrahydrofuran (3.6 L, 3.6 mol) dropwise to the solution obtained in previous step (Crude V=6.5 L, 1.2 mol) at 15° C. over 2 hours 15 minutes then allow to warm to 23° C. After 2 hours 30 minutes the reaction is quenched by pouring into 10% aqueous acetic acid (950 mL). Separate the layers and extract the aqueous layer with ethyl acetate (1.7 L). The organic layers are combined and concentrated in vacuo to obtain a solid which is dissolved in acetone (1.45 L) and added to water (7.3 L). Stir the resulting suspension overnight at 23° C. Filter off the precipitate, wash with water (2×1 L), and dry in the vacuum oven at 40° C. to obtain the title compound (450.67 g, yield 95%). MS (m/z): 418 (M+23).

1. additionis added at 0° C. over 50 minutes
2. customthe reaction
3. filtrationif filtered
4. customto remove triethylamine hydrochloride salt
5. washWash the filter cake with dry tetrahydrofuran (2×2 L)
6. customThe filtrate (13 L) is split into two equal parts
7. customobtained in previous step (Crude V=6.5 L, 1.2 mol) at 15° C. over 2 hours 15 minutes
8. temperatureto warm to 23° C
9. customAfter 2 hours 30 minutes the reaction is quenched
10. additionby pouring into 10% aqueous acetic acid (950 mL)
11. customSeparate the layers
12. extractionextract the aqueous layer with ethyl acetate (1.7 L)
13. concentrationconcentrated in vacuo
14. customto obtain a solid which
15. filtrationFilter off the precipitate
16. washwash with water (2×1 L)
17. customdry in the vacuum oven at 40° C.