Hydrochloric Acid → HCID 89754304, compound

HRID 2173126Notes

Reaction equation

HRID 2173126 reaction equation
[CH3:1][S:2][C:3]1[C:11]2[CH2:10][O:9][C:8](=[O:12])[C:7]=2[CH:6]=[CH:5][C:4]=1[CH2:13][CH2:14][N:15]1[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]1.[ClH:28]>O1CCOCC1>[Cl-:28].[CH3:1][S:2][C:3]1[C:11]2[CH2:10][O:9][C:8](=[O:12])[C:7]=2[CH:6]=[CH:5][C:4]=1[CH2:13][CH2:14][N:15]1[CH2:16][CH2:17][NH2+:18][CH2:19][CH2:20]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 89754885HCID 89754885, compound

Product 1

HCID 89754304HCID 89754304, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In a 12 mL reaction vial, was added tert-butyl 4-(2-[4-(methylsulfanyl)-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazine-1-carboxylate (25 mg, 0.064 mmol) and 4 N HCl in dioxane (1 mL). The reaction was stirred at r. t. for 18 hr. The reaction mixture was concentrated to give the desired product.

Workup

  1. customIn a 12 mL reaction vial
  2. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-32f3391552d14dd5ae08dd5efb975a12
Source dataset
uspto-grants-2015_06
Patent number
US09056859B2

Reaction notes

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