Tert-butyl (1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetate → (1-Oxo-1,3-dihydro-2-benzofuran-5-yl)acetic acid

HRID 2173178Notes

Reaction equation

HRID 2173178 reaction equation
[O:1]=[C:2]1[C:6]2[CH:7]=[CH:8][C:9]([CH2:11][C:12]([O:14]C(C)(C)C)=[O:13])=[CH:10][C:5]=2[CH2:4][O:3]1>C(O)(C(F)(F)F)=O>[O:1]=[C:2]1[C:6]2[CH:7]=[CH:8][C:9]([CH2:11][C:12]([OH:14])=[O:13])=[CH:10][C:5]=2[CH2:4][O:3]1

Participants

3

Reactant 1

HCID 77230657Tert-butyl (1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetate

Product 1

HCID 67518033(1-Oxo-1,3-dihydro-2-benzofuran-5-yl)acetic acid

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

tert-Butyl (1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetate (1.2 g, 4.8 mmol) was dissolved in TFA and stirred at room temperature for one h. The reaction mixture was concentrated and pumped under vacuum overnight to afford the title compound. LC-MS (IE, m/z): 193.2 [M+1]+.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. custompumped under vacuum overnight

Sources & evidence

ORD record
ord-c62a8fe2907d4f8b86e5442bd5f96207
Source dataset
uspto-grants-2015_06
Patent number
US09056859B2

Reaction notes

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