(3-Methoxy-4-nitrophenyl)acetic acid → HCID 18959618, compound

HRID 2173403Notes

Reaction equation

HRID 2173403 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:12][C:13]([OH:15])=[O:14])[CH:6]=[CH:7][C:8]=1[N+:9]([O-])=O>CCOC(C)=O.[Pd]>[NH2:9][C:8]1[CH:7]=[CH:6][C:5]([CH2:12][C:13]([OH:15])=[O:14])=[CH:4][C:3]=1[O:2][CH3:1]

Participants

4

Reactant 1

HCID 16755859(3-Methoxy-4-nitrophenyl)acetic acid

Product 1

HCID 18959618HCID 18959618, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of (3-methoxy-4-nitrophenyl)acetic acid (2.08 g, 9.86 mmol) in 100 mL of EtOAc was added 600 mg of Pd/C under Ar, and the mixture was stirred at ambient temperature under H2 atmosphere overnight. The reaction mixture was filtered and the filtrate was concentrated to give (4-amino-3-methoxyphenyl)acetic acid.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-ab1ad6dd398441939d861f6b455a6c3e
Source dataset
uspto-grants-2015_06
Patent number
US09056859B2

Reaction notes

Loading…