反应详情

A solution of 4-(2,2-dibromovinyl)-5-methyl-1-tosyl-7-vinyl-1H-indole (57 mg, 0.115 mmol) and 3,4-diaminobenzonitrile (23 mg, 0.173 mmol) and DABCO (38.7 mg, 0.345 mmol) in NMP (0.5 mL) was stirred at 110° C. After 80 minutes the mixture was slowly cooled to room temperature overnight, and then heated again at 110° C. for 4 hours. The reaction was cooled to room temperature and loaded onto silica gel and purified by flash chromatography (0-100% EtOAc in heptanes) to provide the title compound. MS (ESI+) m/z 467.2 (M+H).

1. temperatureheated again at 110° C. for 4 hours
2. temperatureThe reaction was cooled to room temperature
3. custompurified by flash chromatography (0-100% EtOAc in heptanes)