反应详情

温度

75 °C

Potassium carbonate (1.38 g, 10 mmol) was added to a solution of 2,4-dihydro-2,5-dimethyl-3H-pyrazol-3-one (0.70 g, 6.3 mmol) in N,N-dimethylformamide (15 mL). 3,4,5-Trifluorobenzonitrile (0.94 g, 6.0 mmol) was added, and the reaction mixture was heated at 75° C. under a nitrogen atmosphere for 16 h, then allowed to cool. The reaction mixture was partitioned between water (60 mL) and ethyl acetate (30 mL). The organic phase was washed with water (2×30 mL) and brine (30 mL), dried over MgSO4, and concentrated to give the title compound as a yellow oil (1.38 g).

1. temperatureto cool
2. customThe reaction mixture was partitioned between water (60 mL) and ethyl acetate (30 mL)
3. washThe organic phase was washed with water (2×30 mL) and brine (30 mL)
4. dry with materialdried over MgSO4
5. concentrationconcentrated