反应详情

NaH as a 60% dispersion in mineral oil (31.63 mg, 0.7908 mmol) was added to a solution of benzyl alcohol (85.52 mg, 81.84 μL, 0.7908 mmol) in THF (4 mL). After stirring at ambient temperature for 5 minutes, 3,5-dibromopyrazin-2-amine (100 mg, 0.3954 mmol) was added and the mixture was stirred for 1 hour at ambient temperature then heated at 80° C. under microwave conditions for 15 minutes. The reaction mixture was cooled to ambient temperature, concentrated in vacuo and used directly in the next step without further purification.

1. stirringthe mixture was stirred for 1 hour at ambient temperature
2. temperaturethen heated at 80° C. under microwave conditions for 15 minutes
3. temperatureThe reaction mixture was cooled to ambient temperature
4. concentrationconcentrated in vacuo
5. customused directly in the next step without further purification