HCID 178480077, compound → HCID 178480078, compound

HRID 2174707Notes

Reaction equation

HRID 2174707 reaction equation
[CH3:1][N:2]1[CH2:8][CH2:7][C:6]2[CH:9]=[C:10]([NH:13][C:14]([C@H:16]([NH:24]C(=O)OC(C)(C)C)[CH2:17][CH2:18][C:19]3[NH:23][N:22]=[N:21][N:20]=3)=[O:15])[CH:11]=[CH:12][C:5]=2[CH2:4][CH2:3]1>Cl>[NH2:24][C@H:16]([CH2:17][CH2:18][C:19]1[NH:23][N:22]=[N:21][N:20]=1)[C:14]([NH:13][C:10]1[CH:11]=[CH:12][C:5]2[CH2:4][CH2:3][N:2]([CH3:1])[CH2:8][CH2:7][C:6]=2[CH:9]=1)=[O:15]

Participants

3

Reactant 1

HCID 178480077HCID 178480077, compound

Product 1

HCID 178480078HCID 178480078, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

49.8 mg (90 μmol) tert.butyl(R)-[1-(3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylcarbamoyl)-3-(1H-tetrazol-5-yl)-propyl]-carbamate are stirred in 1 ml of 2 molar aqueous hydrochloric acid at 50° C. for 2.5 h and then evaporated to dryness.

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-f75b67a32b824c2eab855df83d272f85
Source dataset
uspto-grants-2015_06
Patent number
US09062034B2

Reaction notes

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