Lithium Hydroxide → HCID 59452253, compound

HRID 2174720Notes

Reaction equation

HRID 2174720 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][CH:10]([CH2:15][O:16][CH2:17][CH2:18][O:19][CH3:20])[C:11]([O:13]C)=O)=[O:8])=[CH:4][CH:3]=1.[OH-].[Li+].[CH3:23][N:24]1[CH2:30][CH2:29][C:28]2[CH:31]=[C:32]([NH2:35])[CH:33]=[CH:34][C:27]=2[CH2:26][CH2:25]1.CCOC1N(C(OCC)=O)C2C(=CC=CC=2)C=C1>>[CH3:20][O:19][CH2:18][CH2:17][O:16][CH2:15][CH:10]([NH:9][C:7]([C:5]1[S:6][C:2]([Cl:1])=[CH:3][CH:4]=1)=[O:8])[C:11](=[O:13])[NH:35][C:32]1[CH:33]=[CH:34][C:27]2[CH2:26][CH2:25][N:24]([CH3:23])[CH2:30][CH2:29][C:28]=2[CH:31]=1

Participants

5

Reactant 4

HCID 3939Lithium HydroxideHCID 278332-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinolineHCID 21822925HCID 21822925, compoundHCID 67455828HCID 67455828, compound

Product 1

HCID 59452253HCID 59452253, compound

Procedure

The title compound is prepared from methyl 2-(5-chlorothiophen-2yl)carbonylamino-3-(2-methoxyethyloxy)propionate by lithium hydroxide saponification and subsequent reaction with 3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamine with EEDQ analogously to Example 58(c).

Sources & evidence

ORD record
ord-8ef023eac50d40e4ba9a19b843abc868
Source dataset
uspto-grants-2015_06
Patent number
US09062034B2

Reaction notes

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