反应详情

温度

60 °C

5 g of 5-bromo-4-methyl-1H-indazole was dissolved in 110 ml DMF and treated with 11.5 g of caesium carbonate and 7.9 g of N-Boc-4-(bromomethyl)piperidine. The mixture was stirred for 3 hrs at 60° C. and overnight at RT. The reaction mixture was next diluted with ethyl acetate, and the organic phase was washed twice with water, dried over sodium sulphate, filtered and concentrated. The residue was purified chromatographically on the Biotage SP4 via a 65i-Si column Gradient: hexane/ethyl acetate 0-100%. Yield: 3.53 g of the title compound.

1. washthe organic phase was washed twice with water
2. dry with materialdried over sodium sulphate
3. filtrationfiltered
4. concentrationconcentrated
5. customThe residue was purified chromatographically on the Biotage SP4 via a 65i-Si column Gradient