Hydrochloric Acid → 4-(1-piperazinyl)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)Pyrimidine

HRID 2175075Notes

Reaction equation

HRID 2175075 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][N:17]=[C:16]([C:20]3[CH:29]=[CH:28][C:27]4[C:26]([CH3:31])([CH3:30])[CH2:25][CH2:24][C:23]([CH3:33])([CH3:32])[C:22]=4[CH:21]=3)[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>>[N:11]1([C:14]2[CH:19]=[CH:18][N:17]=[C:16]([C:20]3[CH:29]=[CH:28][C:27]4[C:26]([CH3:31])([CH3:30])[CH2:25][CH2:24][C:23]([CH3:33])([CH3:32])[C:22]=4[CH:21]=3)[N:15]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 672484304-[2-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-pyrimidin-4-yl]piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 532508844-(1-piperazinyl)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)Pyrimidine

Procedure

The above compound is prepared analogously to FS201 starting from 4-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)pyrimidin-4-yl]piperazine-1-carboxylic acid tert-butyl ester. Product is the hydrochloride.

Workup

  1. customThe above compound is prepared analogously to FS201

Sources & evidence

ORD record
ord-1835c933e3f44bccb49b49ed2bea5d03
Source dataset
uspto-grants-2015_06
Patent number
US09062015B2

Reaction notes

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