Triethylamine → HCID 53250711, compound

HRID 2175082Notes

Reaction equation

HRID 2175082 reaction equation
[CH3:1][C:2]1([CH3:26])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([C:14]3[N:19]=[C:18]([N:20]4[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]4)[CH:17]=[CH:16][CH:15]=3)[CH:5]=[CH:4][C:3]1=2.Cl[CH2:28][CH2:29][CH2:30][OH:31].C(N(CC)CC)C>C(O)C>[CH3:1][C:2]1([CH3:26])[CH2:11][CH2:10][C:9]([CH3:12])([CH3:13])[C:8]2[CH:7]=[C:6]([C:14]3[N:19]=[C:18]([N:20]4[CH2:21][CH2:22][N:23]([CH2:28][CH2:29][CH2:30][OH:31])[CH2:24][CH2:25]4)[CH:17]=[CH:16][CH:15]=3)[CH:5]=[CH:4][C:3]1=2

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 123133-Chloro-1-propanolHCID 53250560HCID 53250560, compound

Product 1

HCID 53250711HCID 53250711, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

88 mg (0.25 mmol) of 1-[6-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)pyridin-2-yl]piperazine are irradiated in the microwave at 140° C. for 2 h with 42 μl (0.50 mmol) of 3-chloropropan-1-ol in 2 ml of ethanol and 70 μl (0.50 mmol) of triethylamine. The reaction mixture is evaporated and purified by means of preparative HPLC.

Workup

  1. customThe reaction mixture is evaporated
  2. custompurified by means of preparative HPLC

Sources & evidence

ORD record
ord-6c2c8a8a87f442ed9a7be57949601ed5
Source dataset
uspto-grants-2015_06
Patent number
US09062015B2

Reaction notes

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