HRID2175100

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID81531

Diisopropylethylamine

C8H19N

结构：CC1(C)CCC(C)(C)c2cc(-c3cccc(N4CCC(=O)CC4)n3)ccc21

HCID67248401

未命名化合物

HCID67248684

未命名化合物

PRODUCTS

生成物

结构：CC1(C)CCC(C)(C)c2cc(-c3cccc(N4CCC(N[C@H]5CC[C@H](O)[C@@H]5O)CC4)n3)ccc21

HCID68380227

未命名化合物

PROCEDURE

实验过程

The preparation is carried out analogously to FS1007 without addition of DIPEA starting from 23 mg (0.199 mmol) of (1S,2R,3S)-3-aminocyclopentane-1,2-diol and 80 mg (0.199 mmol) of 6′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-2,3,5,6-tetrahydro-1,2′-bipyridinyl-4-one. The product is in the form of the hydrochloride.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-db6dc376f49743d096767f132df1a6a6
来源数据集: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09062015B2
来源说明: uspto-grants-2015_06

反应 SMILES

CCN(C(C)C)C(C)C.[NH2:10][C@H:11]1[CH2:15][CH2:14][C@H:13]([OH:16])[C@@H:12]1[OH:17].[CH3:18][C:19]1([CH3:44])[CH2:28][CH2:27][C:26]([CH3:30])([CH3:29])[C:25]2[CH:24]=[C:23]([C:31]3[N:36]=[C:35]([N:37]4[CH2:42][CH2:41][C:40](=O)[CH2:39][CH2:38]4)[CH:34]=[CH:33][CH:32]=3)[CH:22]=[CH:21][C:20]1=2.Cl>>[CH3:18][C:19]1([CH3:44])[CH2:28][CH2:27][C:26]([CH3:29])([CH3:30])[C:25]2[CH:24]=[C:23]([C:31]3[N:36]=[C:35]([N:37]4[CH2:42][CH2:41][CH:40]([NH:10][C@H:11]5[CH2:15][CH2:14][C@H:13]([OH:16])[C@@H:12]5[OH:17])[CH2:39][CH2:38]4)[CH:34]=[CH:33][CH:32]=3)[CH:22]=[CH:21][C:20]1=2