Hydrochloric Acid → HCID 86731174, compound

HRID 2175371Notes

Reaction equation

HRID 2175371 reaction equation
[ClH:1].C(OC([N:9]1[CH2:15][CH2:14][CH2:13][N:12]([C:16]([C:18]2[CH:19]=[C:20]3[NH:29][C:28](=[O:30])[C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[N:21]3[CH:31]=2)=[O:17])[CH2:11][CH2:10]1)=O)(C)(C)C>CO>[ClH:1].[N:12]1([C:16]([C:18]2[CH:19]=[C:20]3[NH:29][C:28](=[O:30])[C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[N:21]3[CH:31]=2)=[O:17])[CH2:13][CH2:14][CH2:15][NH:9][CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71487217HCID 71487217, compound

Product 1

HCID 86731174HCID 86731174, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

10% hydrogen chloride in methanol (3 mL) was added to a solution of 2-[4-(tert-butoxycarbonyl)homopiperazine-1-carbonyl]pyrrolo[1,2-a]quinazolin-5(4H)-one (the above Compound 1-47, 156 mg, 0.380 mmol) in methanol (1 mL), and the reaction solution was stirred overnight at room temperature. The precipitated solid was collected by filtration, and dried under reduced pressure, to obtain the title compound (102 mg, yield: 87%) as a colorless powder.

Workup

  1. filtrationThe precipitated solid was collected by filtration
  2. customdried under reduced pressure

Sources & evidence

ORD record
ord-8174c5286b0345088d67dabda98edb03
Source dataset
uspto-grants-2015_06
Patent number
US09062061B2

Reaction notes

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