反应详情

100 mg of Fe was added intio 3 ml of acetic acid and refluxed for 15 minutes. After lowering the temperature into room temperature, the mixture was added with 1-(difluoromethyl)-3-nitrobenzene (0.2 g, 1.15 mmol) and refluxed again for 1 hour. After addition of 20 ml ethyl acetate, impurities were removed using cellite and the organic layer was concentrated under vacuum. After column chromatography (ethylacetate/n-hexane, 1/15), the title compound (0.16 g, 50%) was obtained.

1. temperaturerefluxed for 15 minutes
2. custominto room temperature
3. temperaturerefluxed again for 1 hour
4. customwere removed
5. concentrationthe organic layer was concentrated under vacuum