反应详情

2-methyl-5-nitroindole (2 g, 8.78 mmol) was dissolved into 80 ml of dichloromethane, and then sodium hydroxide (1.1 g, 26.36 mmol), tetrabutylammonium bromide (32 mg, 0.87 mmol), and 4-nitrophenyl chloroformate (1.86 g, 9.22 mmol) were sequentially added followed by stirring at room temperature for 1 hour. After filtering out the solid made in the reaction, the reaction mixture was washed with dichloromethane. The resultant liquid layer was concentrated and 2-methyl-5-nitro-1-(4-nitrophenoxycarbonyl)indole (2.9 g, 96%) was obtained as yellow solid.

1. filtrationAfter filtering out the solid
2. custommade in the reaction
3. washthe reaction mixture was washed with dichloromethane
4. concentrationThe resultant liquid layer was concentrated