P-Cresol → HCID 123254270, compound

HRID 2175477Notes

Reaction equation

HRID 2175477 reaction equation
[CH:1]1[C:6]([OH:7])=[CH:5][CH:4]=[C:3]([CH3:8])[CH:2]=1.Cl[CH2:10][CH2:11][CH2:12][Si:13]([O:18][CH3:19])([O:16][CH3:17])[O:14][CH3:15]>>[OH:7][C:6]1[CH:5]=[CH:4][C:3]([CH3:8])=[CH:2][C:1]=1[CH2:10][CH2:11][CH2:12][Si:13]([O:18][CH3:19])([O:16][CH3:17])[O:14][CH3:15]

Participants

3

Reactant 2

HCID 2879P-CresolHCID 624493-(Trimethoxysilyl)propyl chloride

Product 1

HCID 123254270HCID 123254270, compoundYield 99%

Procedure

As shown in Scheme 2, a new 3-arylpropyl trimethoxysilane compound, 3-(2-hydroxy-5-methylphenyl)-propyltrimethoxysilane (abbreviated PholTMS) was synthesized. 60 g of p-cresol and 100 g of 3-chloropropyltrimethoxysilane were mixed under reflux for 24 hours. The product was confirmed by NMR spectrum, and the yield was more than 99%. 1H NMR of PholTMS (400 MHz, CD3OD): δ0.65 (t, 2H), 1.56 (p, 2H), 2.34 (s, 3H), 2.63 (t, 2H), 3.58 (s, 9H), 6.5-7 (m, 3H).

Workup

  1. temperatureunder reflux for 24 hours

Sources & evidence

ORD record
ord-a5fbae49ff2b423eb87b2a9fc983e425
Source dataset
uspto-grants-2015_06
Patent number
US09062081B1

Reaction notes

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