Hydrochloric Acid → HCID 58562799, compound

HRID 2175503Notes

Reaction equation

HRID 2175503 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][CH:8]([CH:11]([NH:14]S(C(C)(C)C)=O)[CH:12]=[CH2:13])[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.Cl>CO>[O:1]1[C:5]2([CH2:10][CH2:9][CH:8]([CH:11]([NH2:14])[CH:12]=[CH2:13])[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68003945HCID 68003945, compound

Product 1

HCID 58562799HCID 58562799, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of N-(1-(1,4-dioxaspiro[4.5]decan-8-yl)allyl)-2-methylpropane-2-sulfinamide (1.38 g, 4.58 mmol), prepared in the previous step, was dissolved in methanol (100 mL) and treated with HCl (15 mL. 18.7 mmol, 1.25 M in MeOH), stirring overnight at room temperature. The reaction mixture was concentrated in vacuo, triturated with ether, decanting the supernatant several times and the residue dried under high vacuum afford the product as a white foam (HCl salt).

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customtriturated with ether
  3. customdecanting the supernatant several times
  4. customthe residue dried under high vacuum
  5. customafford the product as a white foam (HCl salt)

Sources & evidence

ORD record
ord-f5a9c549f50d4eb3ac07e363237067ff
Source dataset
uspto-grants-2015_06
Patent number
US09062048B2

Reaction notes

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