反应详情

To a stirred solution of 7-bromo-1-chloroisoquinoline (15 g, 62 mmol) in THF at −78° C., n-BuLi (123.7 mmol) was added. The resulting solution was stirred for 15 min. and, I2 (31.4 mg, 123.7 mmol) in THF was slowly added by syringe over a period of 5 min. The solution was then allowed to reach room temperature and treated with a saturated aqueous Na2S2O3 solution. The resulting mixture was extracted with diethyl ether (2×). The extracted organic layer was washed with brine, dried over Na2SO4 and concentrated in vacuum. The residue was purified by flash chromatography to give the title compound.

1. customto reach room temperature
2. extractionThe resulting mixture was extracted with diethyl ether (2×)
3. washThe extracted organic layer was washed with brine
4. dry with materialdried over Na2SO4
5. concentrationconcentrated in vacuum
6. customThe residue was purified by flash chromatography