反应详情

A solution of 3-bromo-6-fluoro-2-methoxybenzamide (14 g, 61 mmol) in 100 mL of DMF was added 2,4,6-trichloro-[1,3,5]triazine (12.3 g, 67.0 mmol) portionwise at 0° C. and stirred for 2 hours before poured to ice/water. The white solid was collected by filtration and was washed with water, dissolved in DCM, dried over anhydrous Na2SO4 and concentrated to afford 3-bromo-6-fluoro-2-methoxybenzonitrile. 1H-NMR (400 MHz, CDCl3) δ ppm 7.71˜7.74 (m, 1H), 6.84˜6.88 (m, 1H), 4.09 (s, 3H);

1. filtrationThe white solid was collected by filtration
2. washwas washed with water
3. dissolutiondissolved in DCM
4. dry with materialdried over anhydrous Na2SO4
5. concentrationconcentrated