Hydrochloric Acid → HCID 90370160, compound

HRID 2176035Notes

Reaction equation

HRID 2176035 reaction equation
[N:1]1([CH2:7][C:8]2[S:12][C:11]([C:13]([O:15]C)=[O:14])=[CH:10][CH:9]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[ClH:17]>>[ClH:17].[N:1]1([CH2:7][C:8]2[S:12][C:11]([C:13]([OH:15])=[O:14])=[CH:10][CH:9]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 68802969HCID 68802969, compound

Product 1

HCID 90370160HCID 90370160, compound

Conditions

Temperature
100 °C

Procedure

A mixture of 3.01 g of methyl 5-(morpholin-4-ylmethyl)thiophene-2-carboxylate and 30 mL of 6.0 M hydrochloric acid was subjected to heating under reflux overnight at 100° C. The reaction mixture was concentrated under reduced pressure, and the residue was washed with acetonitrile, thereby obtaining 3.05 g of 5-(morpholin-4-ylmethyl)thiophene-2-carboxylic acid hydrochloride.

Workup

  1. temperatureto heating
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. washthe residue was washed with acetonitrile

Sources & evidence

ORD record
ord-ae05f8f1a2144a68a9954a6788c5b044
Source dataset
uspto-grants-2015_06
Patent number
US09062032B2

Reaction notes

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