Formaldehyde → HCID 13157916, compound
Reaction equation
[C:1]([O:7][CH2:8][CH3:9])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].[CH2:10]=[O:11].C(N(CC)CC)C.[O:19]1CCOC[CH2:20]1>O>[OH:19][CH2:20][C:2]([CH2:10][OH:11])([C:3](=[O:4])[CH3:5])[C:1]([O:7][CH2:8][CH3:9])=[O:6]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 37.5 °C
Procedure
To a stirred solution of ethyl acetoacetate (150 g, 1.2 mol) in formaldehyde (210 mL, 2.8 mol, 40% aq.) and dioxane (550 mL) was added dropwise triethylamine (1.0 M in tetrahydrofuran, 57 mL, 0.06 mol) at 0° C. The temperature was raised up to 35-40° C. and the mixture was stirred for 1 h. The reaction mixture was diluted with water (400 mL), and the side products were extracted with toluene (3×600 mL). The aqueous phase was evaporated at 35° C. to one fourth of the initial volume and extracted with ethyl acetate (3×900 mL). The extracts were dried over sodium sulfate and evaporated to get the crude product (75 g) as yellow oil, which was used directly to the next step without purification.
Workup
- extractionthe side products were extracted with toluene (3×600 mL)
- customThe aqueous phase was evaporated at 35° C. to one fourth of the initial volume
- extractionextracted with ethyl acetate (3×900 mL)
- dry with materialThe extracts were dried over sodium sulfate
- customevaporated
Sources & evidence
- ORD record
- ord-f4ac4a52b0ad4d7a8663684e5fe71804
- Source dataset
- uspto-grants-2015_06
- Patent number
- US09062092B2
Reaction notes
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