反应详情

A mixture of toluene (13 mL) and water (3.25 mL) was deoxygenated by bubbling nitrogen through for 20 minutes. It was then added to 6-nitromethylene-[1,4]dioxepane (512 mg, 3.22 mmol). 2,2′-Bis(diphenylphosphino)-1,1′-binaphthalene (218 mg, 0.35 mmol) and potassium vinyltrifluoroborate (1.73 g, 12.9 mmol) were added and the mixture was deoxygenated by bubbling nitrogen through for 5 minutes. Bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate (131 mg, 0.32 mmol) was added and the reaction mixture was stirred and heated at reflux under nitrogen for 4.5 h. The mixture was allowed to cool and was partitioned between diethyl ether and water. The aqueous layer was separated and extracted with diethyl ether and the combined organics extracts were dried over anhydrous sodium sulfate, filtered and evaporated. The residue was purified by silica gel chromatography using a gradient of iso-hexanes/diethyl ether 3:1 to 13:7 to give the title compound (155 mg, 26%) as a pale brown oil. 1H NMR (300 MHz, CDCl3) δ 3.77-3.93 (m, 8H), 4.64 (s, 2H), 5.22 (d, J=17.9 Hz, 1H), 5.30 (d, J=11.2 Hz, 1H), 5.79 (dd, J=17.8, 11.2 Hz, 1H). LCMS (m/z) 210.1 [M+Na], Tr=1.51 min.

1. customwas deoxygenated
2. customby bubbling nitrogen through for 20 minutes
3. customthe mixture was deoxygenated
4. customby bubbling nitrogen through for 5 minutes
5. temperatureheated
6. temperatureat reflux under nitrogen for 4.5 h
7. temperatureto cool
8. customwas partitioned between diethyl ether and water
9. customThe aqueous layer was separated
10. extractionextracted with diethyl ether
11. dry with materialthe combined organics extracts were dried over anhydrous sodium sulfate
12. filtrationfiltered
13. customevaporated
14. customThe residue was purified by silica gel chromatography