Hydrochloric Acid → 7-Amino-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile hydrochloride

HRID 2177073Notes

Reaction equation

HRID 2177073 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:18]#[N:19])=[CH:13][CH:14]=2)[CH:9]1[CH2:20][C:21]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=1)(C)(C)C.Cl>ClCCl.C(O)(C)C>[ClH:27].[NH2:7][CH:8]1[CH:9]([CH2:20][C:21]2[CH:22]=[CH:23][C:24]([Cl:27])=[CH:25][CH:26]=2)[C:10]2[CH:11]=[C:12]([C:18]#[N:19])[CH:13]=[CH:14][C:15]=2[CH2:16][CH2:17]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57471190HCID 57471190, compound

Product 1

HCID 574711857-Amino-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile hydrochloride

Reagents, catalysts & solvents 2

HCID 3776IsopropanolSolventHCID 6344DichloromethaneSolvent

Procedure

Tert-butyl[1-(4-chlorobenzyl)-7-cyano-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate (15 mg, 0.038 mmol) was dissolved in dichloromethane (1.5 mL) and 5 M hydrochloric acid in isopropanol (0.3 mL) was added. The reaction mixture was stirred for 3 h at room temperature. The solvent and the excess hydrochloric acid were evaporated in vacuo. Yield: 11 mg (0.033 mmol, 87%, colorless solid).

Workup

  1. customThe solvent and the excess hydrochloric acid were evaporated in vacuo

Sources & evidence

ORD record
ord-ddd0681d0eb745bcb74f94d96345477d
Source dataset
uspto-grants-2015_06
Patent number
US09067871B2

Reaction notes

Loading…