反应详情

温度

120 °C

7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalene-2-carbonitrile (790 mg, 3.03 mmol), 1,3-dibromopropane (0.4 mL, 3.93 mmol) and triethylamine (0.914 mL, 6.56 mmol) were dissolved in acetonitrile (8 mL) and the reaction mixture heated to 120° C. in the microwave for 2 h. The solvent was evaporated in vacuo. Water (30 mL) and ethyl acetate (40 mL) were added. The layers were separated and the aqueous layer extracted with ethyl acetate. The combined organic extracts were dried (MgSO4) and the solvent evaporated in vacuo. The crude product was purified by flash chromatography (silica gel, dichloromethane, methanol). Yield: 346 mg (1.14 mmol, 37.6%).

1. customThe solvent was evaporated in vacuo
2. additionWater (30 mL) and ethyl acetate (40 mL) were added
3. customThe layers were separated
4. extractionthe aqueous layer extracted with ethyl acetate
5. dry with materialThe combined organic extracts were dried (MgSO4)
6. customthe solvent evaporated in vacuo
7. customThe crude product was purified by flash chromatography (silica gel, dichloromethane, methanol)