反应详情

3-Hydroxy-5-trifluoromethylbenzoic acid (2 g) was initially charged at RT in DMF (15 ml) while stirring, and admixed dropwise with methyl iodide (3.0 ml). After adding potassium carbonate (5.6 g), the mixture was stirred for 5 h and left to stand overnight. It was then admixed with water and extracted three times with MtB ether. The combined MTB ether phases were dried over sodium sulfate, filtered and concentrated. 2.29 g of the title compound were obtained.

1. stirringthe mixture was stirred for 5 h
2. waitleft
3. extractionextracted three times with MtB ether
4. dry with materialThe combined MTB ether phases were dried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated