HCID 90409398, compound → HCID 90409551, compound

HRID 2177641Notes

Reaction equation

HRID 2177641 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[CH:15]([CH3:17])[CH2:14][N:13](CC(C4C=CC(OC)=CC=4)(O)C)[CH:12]([CH3:30])[C:11]=3[N:10]=[N:9]2)=[CH:4][CH:3]=1>Cl.O1CCOCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:16]3[CH:15]([CH3:17])[CH2:14][NH:13][CH:12]([CH3:30])[C:11]=3[N:10]=[N:9]2)=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 90409398HCID 90409398, compound

Product 1

HCID 90409551HCID 90409551, compoundYield 92.3%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
90 °C

Procedure

The product of Example 238, Step 3 (90 mg, 0.22 mmol) was dissolved in a solution of HCl in dioxane (4M, 2 mL). The reaction was heated at 90° C. for 16 h. The solvent was removed in vacuo to afford the title compound (50 mg, 92%). MS (ESI) mass calcd. C13H15FN4, 246.10; m/z found, 247.16 [M+H]+.

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-05d5592fc33c4806adf19ee49ba81df2
Source dataset
uspto-grants-2015_06
Patent number
US09066946B2

Reaction notes

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