(Z)-methyl 6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-3-(furan-3-yl)-2-methoxybenzoate → Ethyl 6-(benzenesulphonylmethyl)-3-(furan-3-yl)-2,4-dimethoxybenzoate

HRID 2177844Notes

Reaction equation

HRID 2177844 reaction equation
C(N(CC)C/C=C\C1C=C(F)C=CC=1S(CC1C(C(OC)=O)=C(OC)C([C:30]2[CH:34]=[CH:33][O:32][CH:31]=2)=CC=1)(=O)=O)C.[C:37]1([S:43]([CH2:46][C:47]2[C:52]([C:53]([O:55][CH2:56][CH3:57])=[O:54])=[C:51]([O:58][CH3:59])[C:50](I)=[C:49]([O:61][CH3:62])[CH:48]=2)(=[O:45])=[O:44])[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1>C1COCC1>[C:37]1([S:43]([CH2:46][C:47]2[C:52]([C:53]([O:55][CH2:56][CH3:57])=[O:54])=[C:51]([O:58][CH3:59])[C:50]([C:30]3[CH:34]=[CH:33][O:32][CH:31]=3)=[C:49]([O:61][CH3:62])[CH:48]=2)(=[O:45])=[O:44])[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1

Participants

4

Reactant 2

HCID 69915014(Z)-methyl 6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-3-(furan-3-yl)-2-methoxybenzoateHCID 86677123HCID 86677123, compound2×

Product 1

HCID 86677122Ethyl 6-(benzenesulphonylmethyl)-3-(furan-3-yl)-2,4-dimethoxybenzoate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared by proceeding in a similar manner to Intermediate 160, starting from ethyl 6-(benzenesulphonylmethyl)-3-iodo-2,4-dimethoxybenzoate (Intermediate 201), using THF instead of dioxane.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-bb5f62407e5443e3abd9496eec4a69b5
Source dataset
uspto-grants-2015_06
Patent number
US09067905B2

Reaction notes

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