反应详情

Methyl(triphenylphosphoranylidene)acetate (8.827 g, 26 mmol, 1.1 eq) is added at room temperature to a solution of 4,4-difluorocyclohexanecarbaldehyde (3.55 g, 24 mmol, 1 eq) in dry THF (60 ml). The mixture is stirred for 6 h and the solvent is evaporated. Hexane (50 ml) is added to the crude, the mixture is put a few minutes in an ultrasonic bath, stirred for 1 h and filtered. The filtrate is concentrated under reduced pressure to afford 4.05 g of methyl 3-(4,4-difluorocyclohexyl)prop-2-enoate a1-16.

1. customthe solvent is evaporated
2. additionHexane (50 ml) is added to the crude
3. waitthe mixture is put a few minutes in an ultrasonic bath
4. stirringstirred for 1 h
5. filtrationfiltered
6. concentrationThe filtrate is concentrated under reduced pressure