Trifluoroacetic acid → HCID 67953983, compound

HRID 2178564Notes

Reaction equation

HRID 2178564 reaction equation
C(OC([N:8]([C:18]1[N:19]=[C:20]2[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][N:21]2[C:30]=1[CH3:31])[S:9]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(=[O:11])=[O:10])=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:31][C:30]1[N:21]2[CH:22]=[C:23]([C:26]([F:27])([F:28])[F:29])[CH:24]=[CH:25][C:20]2=[N:19][C:18]=1[NH:8][S:9]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(=[O:11])=[O:10]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67953948HCID 67953948, compound

Product 1

HCID 67953983HCID 67953983, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of compound 10-F (0.066 g, 0.084 mmol) in methylene chloride (2 mL) was added trifluoroacetic acid (1 mL) and the resulting mixture was stirred at room temperature overnight. The solvent was evaporated in vacuo and the crude product, isolated as a light yellow oil, was used in the next step without further purification; MS m/z (M+H+) 356.

Workup

  1. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-379308ba10a241a284f144ec763e0318
Source dataset
uspto-grants-2015_06
Patent number
US09067935B2

Reaction notes

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