Hydrazine hydrate (1:1) → HCID 68380694, compound

HRID 2178664Notes

Reaction equation

HRID 2178664 reaction equation
[F:1][C:2]1[C:7]2[N:8]=C[S:10][C:6]=2[C:5]([OH:11])=[CH:4][CH:3]=1.O.NN>C(O)C>[NH2:8][C:7]1[C:6]([SH:10])=[C:5]([OH:11])[CH:4]=[CH:3][C:2]=1[F:1]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 683798694-Fluoro-1,3-benzothiazol-7-ol

Product 1

HCID 68380694HCID 68380694, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

A solution of 4-fluoro-1,3-benzothiazol-7-ol (C14) (2.02 g, 11.93 mmol) in ethanol (20 mL) was treated with hydrazine monohydrate (12.7 mL, 167 mmol) and stirred for at 80° C. for 1 hour. The reaction was concentrated in vacuo and used directly in the following step.

Workup

  1. concentrationThe reaction was concentrated in vacuo

Sources & evidence

ORD record
ord-66a30ca9923e4a488453bab305543965
Source dataset
uspto-grants-2015_06
Patent number
US09067934B2

Reaction notes

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