Hydrochloric Acid → HCID 178478720, compound

HRID 2178884Notes

Reaction equation

HRID 2178884 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:21].O>C1COCC1>[ClH:21].[ClH:21].[N:15]1([CH2:14][C@H:11]2[CH2:10][CH2:9][C@H:8]([NH2:7])[CH2:13][CH2:12]2)[CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 178453932HCID 178453932, compound

Product 1

HCID 178478720HCID 178478720, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
65 °C

Procedure

To a solution of tert-butyl(trans-4-(pyrrolidin-1-ylmethyl)cyclohexyl)carbamate (1.3 g, 4.5 mmol) in THF (15 mL) was added aqueous 6 N HCl (6 mL) and water (6 mL) and the reaction mixture was stirred with heat at 65° C. for 3 h. The reaction mixture was cooled to room temperature and concentrated to afford the desired product (1.2 g, >99%) as an off-white solid. ESI MS m/z 183 [C11H22FN2+H]+

Workup

  1. temperatureThe reaction mixture was cooled to room temperature
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-58d2ce886a9b4bd69ed2925c3cfe819b
Source dataset
uspto-grants-2015_06
Patent number
US09067937B2

Reaction notes

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