Hydrochloric Acid → HCID 57414389, compound

HRID 2179309Notes

Reaction equation

HRID 2179309 reaction equation
[C:1]1([S:7]([C:10]2[CH:11]=[CH:12][C:13]3[O:22][C:21]4[CH2:20][CH2:19][NH:18][CH2:17][C:16]=4[C:14]=3[CH:15]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:23]>CO>[ClH:23].[C:1]1([S:7]([C:10]2[CH:11]=[CH:12][C:13]3[O:22][C:21]4[CH2:20][CH2:19][NH:18][CH2:17][C:16]=4[C:14]=3[CH:15]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57414390HCID 57414390, compound

Product 1

HCID 57414389HCID 57414389, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

8-(Phenylsulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine (14 mg, 0.04 mmol) was treated with 1.25M HCl in methanol (3 mL). After stirring for 10 min the reaction mixture was concentrated in vacuo to give 8-(phenylsulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine hydrochloride (12 mg, 88%, AUC HPLC>99%) as a white solid: mp 243° C.: 1H NMR (CD3OD, 300 MHz) δ 8.27 (d, J=1.8 Hz, 1H), 8.01-7.93 (m, 3H), 7.70 (d, J=9.0 Hz, 1H), 7.64-7.53 (m, 3H), 4.48 (t, J=1.8 Hz, 2H), 3.68 (t, J=6.0 Hz, 2H), 3.22-3.17 (m, 2H); ESI MS m/z 314 [M+H]+.

Workup

  1. concentrationwas concentrated in vacuo

Sources & evidence

ORD record
ord-a0e481c982ab4ab29749ddbc25afebe7
Source dataset
uspto-grants-2015_06
Patent number
US09067949B2

Reaction notes

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