Hydrochloric Acid → HCID 68108585, compound

HRID 2179353Notes

Reaction equation

HRID 2179353 reaction equation
[C:1]1([S:7]([C:10]2[CH:15]=[CH:14][C:13]3[C:16]4[CH2:17][NH:18][CH2:19][CH2:20][C:21]=4[O:22][C:12]=3[CH:11]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:23]>>[ClH:23].[C:1]1([S:7]([C:10]2[CH:15]=[CH:14][C:13]3[C:16]4[CH2:17][NH:18][CH2:19][CH2:20][C:21]=4[O:22][C:12]=3[CH:11]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 68108586HCID 68108586, compound

Product 1

HCID 68108585HCID 68108585, compound

Procedure

The product of step E was converted to the HCl salt using the procedure of Example 32, step C providing 7-(phenylsulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine hydrochloride (22 mg, 94%, AUC HPLC 97.4%) as a white solid: mp 235-238° C.: 1H NMR (DMSO-d6, 300 MHz) δ 9.69 (br s, 2H), 8.27 (s, 1H), 7.98 (d, J=6.9 Hz, 2H), 7.89-7.81 (m, 2H), 7.70-7.56 (m, 3H), 4.33 (s, 2H), 3.53 (t, J=6.0 Hz, 2H), 3.16-3.14 (m, 2H); ESI MS m/z 314 [M+H]+.

Sources & evidence

ORD record
ord-a364f808083d48678a622100f6fd5129
Source dataset
uspto-grants-2015_06
Patent number
US09067949B2

Reaction notes

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