(3-Aminopropyl)triethoxysilane → 2-(6-Hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid

HRID 2179551Notes

Reaction equation

HRID 2179551 reaction equation
NCCC[Si:5](OCC)(OCC)OCC.[CH:15]1[C:20](N=C=S)=[CH:19][C:18]2[C:24]([O:26][C:27]3([C:37]4[CH:38]=[CH:39][C:40]([OH:42])=[CH:41][C:36]=4[O:35][C:29]4[CH:30]=[C:31]([OH:34])[CH:32]=[CH:33][C:28]3=4)[C:17]=2[CH:16]=1)=[O:25]>C(C(O)C)C>[CH:15]1[CH:20]=[CH:19][C:18]([C:24]([OH:26])=[O:25])=[C:17]([C:27]2[C:28]3[CH:33]=[CH:32][C:31]([OH:34])=[CH:30][C:29]=3[O:35][C:36]3[C:37]=2[CH:38]=[CH:39][C:40]([CH:41]=3)=[O:42])[CH:16]=1.[SiH4:5]

Participants

5

Reactant 2

HCID 13521(3-Aminopropyl)triethoxysilaneHCID 18730Fluorescein 5-isothiocyanate

Product 2

HCID 33832-(6-Hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acidHCID 23953Silane

Reagents, catalysts & solvents 1

HCID 6568(+-)-2-ButanolSolvent

Procedure

50 μl APS (γ-amino propyltriethoxyl silane) and 1 ml FITC (fluorescein isothiocyanate, 1 mg/ml ethanol solution) are added into a 4 ml absolute ethyl ethanol under obturation condition to react for 12 hours, so as to obtain a precursor solution upon coupling of fluoresceine and silane coupling agent. The method for preparing the precursor solution is common knowledge in prior art. 3.65 ml ethanol/water mixture (ratio of ethanol to water is 8), 1.2 ml ethanol and 100

Workup

  1. customto react for 12 hours

Sources & evidence

ORD record
ord-b356f3e9bd554eda81e0356cf5b4ce32
Source dataset
uspto-grants-2015_06
Patent number
US09068084B2

Reaction notes

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