反应详情

温度

-10 °C

1.23 ml (7.24 mmol) of trifluoromethanesulphonic anhydride are slowly added dropwise to a solution, cooled to −10° C., of 1.0 g (4.83 mmol) of 4-(4-morpholinyl-carbonyl)phenol and 2.02 ml (14.48 mmol) of triethylamine in 20 ml of dichloromethane. The mixture is stirred at −10° C. for 30 min and then at 0° C. for 30 min. It is washed successively with 10% strength sodium bicarbonate solution, water and saturated sodium chloride solution, dried over sodium sulphate and concentrated in vacuo, and the residue is dried under high vacuum. 1.71 g (94.6% of theory) of the title compound are obtained.

1. waitat 0° C. for 30 min
2. washIt is washed successively with 10% strength sodium bicarbonate solution, water and saturated sodium chloride solution
3. dry with materialdried over sodium sulphate
4. concentrationconcentrated in vacuo
5. customthe residue is dried under high vacuum