HCID 86650119, compound → HCID 58111116, compound

HRID 2179758Notes

Reaction equation

HRID 2179758 reaction equation
[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]([C@@H:11]2[CH2:14][C@H:13]([NH:15]C(=O)OCC3C=CC=CC=3)[C:12]2([CH3:27])[CH3:26])=[O:10])[CH2:5][CH2:4]1)[CH3:2]>CCOC(C)=O>[NH2:15][C@H:13]1[CH2:14][C@@H:11]([C:9]([N:6]2[CH2:5][CH2:4][N:3]([CH2:1][CH3:2])[CH2:8][CH2:7]2)=[O:10])[C:12]1([CH3:26])[CH3:27]

Participants

3

Reactant 1

HCID 86650119HCID 86650119, compound

Product 1

HCID 58111116HCID 58111116, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a stirred solution of benzyl (1S,3R)-3-(4-ethylpiperazine-1-carbonyl)-2,2-dimethylcyclobutylcarbamate (above step 1, 780 mg) in EtOAc (20 ml) 10% Pd/C (catalytic amount) was added at room temperature and the reaction mixture was stirred under H2 gas atmosphere for 12 hours. After completion of the reaction (monitored by TLC), the reaction mixture was filtered through a celite bed and the obtained filtrate concentrated under reduced pressure to afford the title compound as a liquid which was proceeded as such for next reaction without characterization. Yield has been calculated as 100%.

Workup

  1. customAfter completion of the reaction (monitored by TLC)
  2. filtrationthe reaction mixture was filtered through a celite bed
  3. concentrationthe obtained filtrate concentrated under reduced pressure

Sources & evidence

ORD record
ord-4e56d6b25f0c4b62997ec312281d6afd
Source dataset
uspto-grants-2015_06
Patent number
US09067966B2

Reaction notes

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