Dichloromethane → 3-Chloro-1-(3-thienyl)-1-propanone

HRID 2179973Notes

Reaction equation

HRID 2179973 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([C:6](=[O:9])[CH:7]=[CH2:8])=[CH:2]1.[Cl:10]CCl>C(OCC)C.Cl>[Cl:10][CH2:8][CH2:7][C:6]([C:3]1[CH:4]=[CH:5][S:1][CH:2]=1)=[O:9]

Participants

5

Reactant 2

HCID 6344DichloromethaneHCID 224899271-(3-Thienyl)-2-propen-1-one

Product 1

HCID 224899023-Chloro-1-(3-thienyl)-1-propanoneYield 91%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 3283Diethyl EtherSolvent2×

Procedure

The product from step (b) (1.288 g, 9.3 mmol) was dissolved in a mixture of diethyl ether (30 ml) and dichloromethane (20 ml) and 1M hydrochloric acid in diethyl ether (25 ml) added. The reaction was stirred for 18 h at room temperature. The solvent was removed in vacuo to give the title compound (1.482 g, 91%).

Workup

  1. additionadded
  2. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-5a3f24bade6d41e8a5539e8cdf4d5aaa
Source dataset
uspto-grants-2005_05
Patent number
US06887871B2

Reaction notes

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