HCID 86759701, compound → HCID 69800369, compound

HRID 2179976Notes

Reaction equation

HRID 2179976 reaction equation
[Cl:1][C:2]1[C:3]([F:27])=[CH:4][C:5]([C:25]#[N:26])=[C:6]([CH:24]=1)[O:7][C@@H:8]([C:19]1[S:20][CH:21]=[CH:22][N:23]=1)[CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C>Cl.O1CCOCC1>[ClH:1].[NH2:11][CH2:10][CH2:9][C@@H:8]([O:7][C:6]1[CH:24]=[C:2]([Cl:1])[C:3]([F:27])=[CH:4][C:5]=1[C:25]#[N:26])[C:19]1[S:20][CH:21]=[CH:22][N:23]=1

Participants

4

Reactant 1

HCID 86759701HCID 86759701, compound

Product 1

HCID 69800369HCID 69800369, compoundYield 155.1%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

The product from step (c) (370 mg, 0.9 mmol) was dissolved in 4M hydrochloric acid in dioxan and stirred at room temperature for a half hour. The solvent was removed in vacuo and the residue triturated with a mixture of ethyl acetate and methanol (14:1). The white solid was filtered and dried to afford the title compound (243 mg, 70%).

Workup

  1. customThe solvent was removed in vacuo
  2. customthe residue triturated with a mixture of ethyl acetate and methanol (14:1)
  3. filtrationThe white solid was filtered
  4. customdried

Sources & evidence

ORD record
ord-9984bde08fea498a8cd56203fb971db2
Source dataset
uspto-grants-2005_05
Patent number
US06887871B2

Reaction notes

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