Sodium Bicarbonate → HCID 69799060, compound

HRID 2179984Notes

Reaction equation

HRID 2179984 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:31]#[N:32])=[C:6]([CH:30]=1)[O:7][C@@H:8]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH2:9][CH2:10][N:11]1[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]1.C(=O)(O)[O-].[Na+]>Cl.O1CCOCC1>[ClH:1].[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:31]#[N:32])=[C:6]([O:7][C@@H:8]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[CH:30]=1

Participants

5

Reactant 2

HCID 516892Sodium BicarbonateHCID 69803723HCID 69803723, compound

Product 1

HCID 69799060HCID 69799060, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

The product from step (a) (0.35 g) was stirred in 4M HCl in dioxane (10 ml) for 3 h, then poured into saturated sodium bicarbonate solution (100 ml) and extracted into ethyl acetate. The extract was evaporated to dryness and the residue triturated with 1N HCl in ether to give the product as a white solid.

Workup

  1. extractionextracted into ethyl acetate
  2. customThe extract was evaporated to dryness
  3. customthe residue triturated with 1N HCl in ether

Sources & evidence

ORD record
ord-95e515d75d1d401f8c31abbb555dda12
Source dataset
uspto-grants-2005_05
Patent number
US06887871B2

Reaction notes

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