Sodium hydride → HCID 90745477, compound

HRID 2179990Notes

Reaction equation

HRID 2179990 reaction equation
[N:1]([CH2:4][CH2:5][C@H:6]([C:8]1[CH:12]=[CH:11][O:10][N:9]=1)[OH:7])=[N+:2]=[N-:3].F[C:14]1[CH:21]=[C:20]([Cl:22])[C:19]([F:23])=[CH:18][C:15]=1[C:16]#[N:17].[H-].[Na+]>>[N:1]([CH2:4][CH2:5][C@@H:6]([O:7][C:14]1[CH:21]=[C:20]([Cl:22])[C:19]([F:23])=[CH:18][C:15]=1[C:16]#[N:17])[C:8]1[CH:12]=[CH:11][O:10][N:9]=1)=[N+:2]=[N-:3]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 112753024-Chloro-2,5-difluorobenzonitrileHCID 91232705HCID 91232705, compound

Product 1

HCID 90745477HCID 90745477, compoundYield 78.4%

Procedure

The product from step (a) (0.1 g) and 2,5-difluoro-4-chloro-benzonitrile (0.18 g) and sodium hydride (60% dispersion in oil, 0.035 g) were subjected to the procedure described in Example 90(a) to afford the product as a gum (0.15 g).

Sources & evidence

ORD record
ord-c87904dda8f2462a86c26e4457249220
Source dataset
uspto-grants-2005_05
Patent number
US06887871B2

Reaction notes

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