反应详情

温度

100 °C

A suspension of 4-chloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)cinnoline (200 mg, 0.62 mmol), (prepared as described for the starting material in Example 1), 5-hydroxyindole (100 mg, 0.75 mmol) and potassium carbonate (129 mg, 0.93 mmol) in DMF (3 ml) was stirred at 100° C. for 6 hours. After cooling, the volatiles were removed under vacuum and the residue was purified by column chromatography eluting with methylene chloride/methanol saturated with ammonia (98/2 to 90/10). The fractions containing the expected product were combined and evaporated to give 4-(indol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)cinnoline (40 mg, 15%).

1. custom(prepared
2. temperatureAfter cooling
3. customthe volatiles were removed under vacuum
4. customthe residue was purified by column chromatography
5. washeluting with methylene chloride/methanol saturated with ammonia (98/2 to 90/10)
6. additionThe fractions containing the expected product
7. customevaporated