1-Methylpiperazine → 2-(N-methylpiperazinyl)ethylphthalimide

HRID 21802Notes

Reaction equation

HRID 21802 reaction equation
Br[CH2:2][CH2:3][C:4]1[CH:14]=[CH:13][CH:12]=[C:6]2[C:7]([NH:9][C:10](=[O:11])[C:5]=12)=[O:8].[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>C(OCC)C>[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH:17]1[CH2:2][CH2:3][C:4]1[CH:14]=[CH:13][CH:12]=[C:6]2[C:7]([NH:9][C:10](=[O:11])[C:5]=12)=[O:8]

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 219600212-Bromoethylphthalimide

Product 1

HCID 544460722-(N-methylpiperazinyl)ethylphthalimide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

2-Bromoethylphthalimide (508 mg; 2.0 mmoles) and N-methylpiperazine (0.44 ml; 4.0 mmoles) were dissolved in anhydrous ethyl ether (5 ml). Reaction times and process as per Example 1.

Workup

  1. customReaction times and process as per Example 1

Sources & evidence

ORD record
ord-4521b61fb1534bbd9013fa2f9ed61a3f
Source dataset
uspto-grants-1995_06
Patent number
US05424451

Reaction notes

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