Methyl morpholine oxide → (2E)-3-(7-Ethoxy-2,2-dimethyl-4-phenyl-2H-chromen-6-yl)-2-fluoro-but-2-enal

HRID 2180516Notes

Reaction equation

HRID 2180516 reaction equation
[CH2:1]([O:3][C:4]1[CH:13]=[C:12]2[C:7]([C:8]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:9][C:10]([CH3:15])([CH3:14])[O:11]2)=[CH:6][C:5]=1/[C:22](/[CH3:27])=[C:23](/[F:26])\[CH2:24][OH:25])[CH3:2].C[N+]1([O-])CCOCC1>>[CH2:1]([O:3][C:4]1[CH:13]=[C:12]2[C:7]([C:8]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:9][C:10]([CH3:15])([CH3:14])[O:11]2)=[CH:6][C:5]=1/[C:22](/[CH3:27])=[C:23](/[F:26])\[CH:24]=[O:25])[CH3:2]

Participants

3

Reactant 2

HCID 82029Methyl morpholine oxideHCID 22490895HCID 22490895, compound2×

Product 1

HCID 22490763(2E)-3-(7-Ethoxy-2,2-dimethyl-4-phenyl-2H-chromen-6-yl)-2-fluoro-but-2-enal

Procedure

Following General Procedure M, (2E)-3-(7-ethoxy-2,2-dimethyl-4 phenyl-2H-chromen-6-yl)-2-fluoro-but-2-en-1-ol (Compound 88, 137 mg, 0.37 mmol) and 4-methylmorpholine N-oxide (87 mg, 0.74 mmol) were reacted to give the title compound as a yellow oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-0aa4e4454ce1422abc9af2e4a950e2c6
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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