Tetrapropylammonium → 1-(8-Chloro-7-isopropoxy-4-isopropyl-2,2-dimethyl-2H-chromene-6-yl)-ethanone

HRID 2180537Notes

Reaction equation

HRID 2180537 reaction equation
[Cl:1][C:2]1[C:3]([O:20][CH:21]([CH3:23])[CH3:22])=[C:4]([CH:17]([OH:19])[CH3:18])[CH:5]=[C:6]2[C:11]=1[O:10][C:9]([CH3:13])([CH3:12])[CH:8]=[C:7]2[CH:14]([CH3:16])[CH3:15].C([N+](CCC)(CCC)CCC)CC.C[N+]1([O-])CCOCC1>>[Cl:1][C:2]1[C:3]([O:20][CH:21]([CH3:23])[CH3:22])=[C:4]([C:17](=[O:19])[CH3:18])[CH:5]=[C:6]2[C:11]=1[O:10][C:9]([CH3:12])([CH3:13])[CH:8]=[C:7]2[CH:14]([CH3:16])[CH3:15]

Participants

4

Reactant 3

HCID 9559TetrapropylammoniumHCID 82029Methyl morpholine oxideHCID 224910421-(8-Chloro-7-isopropoxy-4-isopropyl-2,2-dimethyl-2H-chromene-6-yl)-ethanol2×

Product 1

HCID 224908931-(8-Chloro-7-isopropoxy-4-isopropyl-2,2-dimethyl-2H-chromene-6-yl)-ethanone

Procedure

Following General Procedure M, 1-(8-chloro-7-isopropoxy-4-isopropyl-2,2-dimethyl-2H-chromene-6-yl)-ethanol (Compound 138, 0.92 g, 2.7 mmol), tetrapropylammonium perrunthenate (TPAP, 0.047 g, 0.14 mmol), and 4-methylmorpholine N-oxide (NMO, 0.47 g, 4.1 mmol) were reacted to give the title compound as a yellow oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-b84f0357c27d4fcea997df8f3213f887
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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